In this presentation an overview on our specific naevus-orientated research program carried out in Southeast Queensland will be presented with special emphasis on the preliminary results of our NHMRC grant titled “Effects of naevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of naevi”. In addition, the results of a recent naevus surveillance study on a cohort of high-risk melanoma patients will be presented. And finally, a blueprint for staging of murine melanocytic lesions based on the Cdk4R24C/R24C::Tyr-NRASQ61K model will be discussed.