Actinic lentigines (AL) are benign skin hyperpigmented lesions associated with age and chronic sun exposure. AL develop earlier in Asian than in European skins. To better understand the aetiology of AL in both populations, the gene expression profile of AL from Japanese volunteers was analyzed and compared to previous results obtained on AL from European subjects. AL from the dorsal side of hands of 12 Japanese women were selected on the same epiluminescence criteria as in the European study. A whole genome transcriptomic study showed that 247 genes were differently expressed in AL versus adjacent non lesional skin (|Fold change| > 1.5 and p-value < 0,05). Interestingly, when comparing the Japanese and European AL profiles, we could show that AL lesions selected on the same clinical criteria from Japanese and European women share a common gene expression profile. In both populations, whereas the melanogenesis pathway was not altered, genes involved in multiple biological functions including epidermal proliferation and differentiation, inflammation, oxidative stress response and particularly extracellular matrix organization, were found modulated. In conclusion, European and Japanese AL share similar alterations of multiple actors involved in skin homeostasis, thus emphasizing the interest of a multi-targeted treatment for AL.